PPIRE11091
Target Protein Information
| Protein_Name | Myosin light chain kinase, smooth muscle |
|---|---|
| Protein_Sequence | FIVLSQEGSLCSISIEKALPEDRGLYKCVAKNSAGQAECSCQVTVDDAPTGENAKAPEMKARRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVAGTQPITCTWMKFRKQIQES |
| Organism_Source | Sus scrofa |
| Functional_Classification | kinases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | MYLK |
| UniProt_ID | P79280 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Peptide 8 |
|---|---|
| Peptide_Sequence | KKRAARATSNVFA |
| Peptide_Length | 13 |
| Peptide_SMILES | CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 1419.65 |
|---|---|
| Aliphatic_Index | 53.07692 |
| Aromaticity | 0.07692 |
| Average_Rotatable_Bonds | 3.69231 |
| Charge_at_pH_7 | 3.99739 |
| Isoelectric_Point | 12.53175 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 21 |
| Number_of_Hydrogen_Bond_Donors | 25 |
| Topological_Polar_Surface_Area | 671.91000 |
| X_logP_energy | -8.77276 |
Interaction Information
| Affinity | Ki=24 uM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Minimum requirements for inhibition of smooth-muscle myosin light-chain kinase by synthetic peptides. |
| Release_Year | 1989 |
| PMID | 2920029 |
| DOI | 10.1042/bj2570073 |