PPIRE11093

Target Protein Information
Protein_Name Vitamin D3 receptor
Protein_Sequence MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSSSSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGNEIS
Organism_Source Rattus norvegicus
Functional_Classification nuclear hormone receptors
Cellular_Localization Nucleus
Gene_Names Vdr
UniProt_ID P13053
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DRIP205-2
Peptide_Sequence KNHPMLMNLLKDN
Peptide_Length 13
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1567.88
Aliphatic_Index 90.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.15385
Charge_at_pH_7 1.08875
Isoelectric_Point 9.53937
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 651.02000
X_logP_energy -5.30870
Interaction Information
Affinity KD=9.4 uM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title SRC2-3 binds to vitamin D receptor with high sensitivity and strong affinity.
Release_Year 2017
PMID 27890450
DOI 10.1016/j.bmc.2016.11.020