PPIRE11098

Target Protein Information
Protein_Name Transcription termination/antitermination protein NusA
Protein_Sequence MNKEILAVVEAVSNEKALPREKIFEALESALATATKKKYEQEIDVRVQIDRKSGDFDTFRRWLVVDEVTQPTKEITLEAARYEDESLNLGDYVEDQIESVTFDRITTQTAKQVIVQKVREAERAMVVDQFREHEGEIITGVVKKVNRDNISLDLGNNAEAVILREDMLPRENFRPGDRVRGVLYSVRPEARGAQLFVTRSKPEMLIELFRIEVPEIGEEVIEIKAAARDPGSRAKIAVKTNDKRIDPVGACVGMRGARVQAVSTELGGERIDIVLWDDNPAQFVINAMAPADVASIVVDEDKHTMDIAVEAGNLAQAIGRNGQNVRLASQLSGWELNVMTVDDLQAKHQAEAHAAIDTFTKYLDIDEDFATVLVEEGFSTLEELAYVPMKELLEIEGLDEPTVEALRERAKNALATIAQAQEESLGDNKPADDLLNLEGVDRDLAFKLAARGVCTLEDLAEQGIDDLADIEGLTDEKAGALIMAARNICWFGDEA
Organism_Source Escherichia coli O157:H7
Functional_Classification transcription elongation factor
Cellular_Localization Cytoplasm
Gene_Names nusA
UniProt_ID P0AFF8
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name lambdaN(31-43)
Peptide_Sequence KPVNRPILSLNRK
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1534.87
Aliphatic_Index 112.30769
Aromaticity 0.00000
Average_Rotatable_Bonds 3.92308
Charge_at_pH_7 3.99739
Isoelectric_Point 12.53175
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 677.19000
X_logP_energy -6.44976
Interaction Information
Affinity KD=9.65 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 1U9L
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for the interaction of Escherichia coli NusA with protein N of phage lambda.
Release_Year 2004
PMID 15365170
DOI 10.1073/pnas.0405883101