PPIRE11103

Target Protein Information
Protein_Name Protein Dok-7
Protein_Sequence MTEAALVEGQVKLRDGKKWKSRWLVLRKPSPVADCLLMLVYKDKCERSKGLRERSSLTLEDICGLEPALPYEGLAHTLAIICLSQAVMLGFDSHEAMCAWDTRIRYALGEVHRFHVTVAPGTKLESGPATLHLCNDILVLARDIPPTVMGQWKLSDLRRYGAVPNGFIFEGGTRCGYWAGVFFLSSAEGEQMSFLFDCIVRGISPTKGPFGLRPVLPDPSSGGPSASEERVAQEALEALQLEKRLSLLSHSGRPGSGGDDRSLSSSSSEASHSDISASSRLTAWPEQSSSSAGTSQEGPGLVAAQGPGEAMLGASRPPLKPLRPRQLQEVGRQSSSDSGIATGSHSSYSGSFSSYAGSNLDVWRAGEEFGSLLSLPPGASAPEPRLCACPPGAAEYQVPTSLRHHYDTPRSLRQAPRDPSPASQGSSDHGSATDLGGQAPTGCPSSWLGARRRGQATEGPGSDAALPSPSPGESWEAGSPHAGPPPAFFLSCSICGGLKVKPPP
Organism_Source Mus musculus
Functional_Classification PTB domain-containing proteins
Cellular_Localization Cytoplasm
Gene_Names Dok7
UniProt_ID Q18PE0
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MuSK pTyr553 phosphopeptide
Peptide_Sequence LDRLHPNPMXQRM
Peptide_Length 13
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CC(C)C)C(=O)O
Chemical_Modification X10=phosphotyrosine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1564.84
Aliphatic_Index 60.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.84615
Charge_at_pH_7 1.08933
Isoelectric_Point 10.39953
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 670.90000
X_logP_energy -6.43396
Interaction Information
Affinity KD=4.7 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3ML4
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization.
Release_Year 2010
PMID 20603078
DOI 10.1016/j.molcel.2010.06.007