PPIRE11127
Target Protein Information
| Protein_Name | NAD-dependent protein deacetylase sirtuin-2 |
|---|---|
| Protein_Sequence | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ |
| Organism_Source | Homo sapiens |
| Functional_Classification | lysine deacetylases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | SIRT2 |
| UniProt_ID | Q8IXJ6 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Ran31-43TFAcK37 |
|---|---|
| Peptide_Sequence | LTGEFEXKYVATL |
| Peptide_Length | 13 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)O |
| Chemical_Modification | X7=trifluoroacetyl-L-lysine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1427.62 |
|---|---|
| Aliphatic_Index | 90.00000 |
| Aromaticity | 0.15385 |
| Average_Rotatable_Bonds | 3.53846 |
| Charge_at_pH_7 | -0.99961 |
| Isoelectric_Point | 4.25815 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 20 |
| Number_of_Hydrogen_Bond_Donors | 20 |
| Topological_Polar_Surface_Area | 573.83000 |
| X_logP_energy | -3.94200 |
Interaction Information
| Affinity | KD=1.3 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Insights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins. |
| Release_Year | 2016 |
| PMID | 27226597 |
| DOI | 10.1074/jbc.M116.726307 |