PPIRE11128

Target Protein Information
Protein_Name NAD-dependent protein deacetylase sirtuin-2
Protein_Sequence MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
Organism_Source Homo sapiens
Functional_Classification lysine deacetylases
Cellular_Localization Cytoplasm
Gene_Names SIRT2
UniProt_ID Q8IXJ6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ran31-43TFAcK37/38
Peptide_Sequence LTGEFEXXYVATL
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)O
Chemical_Modification X7=trifluoroacetyl-L-lysine; X8=trifluoroacetyl-L-lysine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1356.49
Aliphatic_Index 90.00000
Aromaticity 0.15385
Average_Rotatable_Bonds 3.23077
Charge_at_pH_7 -1.99932
Isoelectric_Point 3.61369
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 547.81000
X_logP_energy -4.43960
Interaction Information
Affinity KD=1 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Insights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins.
Release_Year 2016
PMID 27226597
DOI 10.1074/jbc.M116.726307