PPIRE11161

Target Protein Information
Protein_Name Endothelin-1 receptor
Protein_Sequence METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names EDNRA
UniProt_ID P25101
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ET-1
Peptide_Sequence XXXXXXXXXXXXXXXXXXXXX
Peptide_Length 21
Peptide_SMILES NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method Side chain cyclization; C1<->C15; disulfide bond; C3<->C11; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1216.11
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 1.95238
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 645.32000
X_logP_energy -18.64630
Interaction Information
Affinity KD=0.21 nM
Affinity_Assay receptor autoradiography
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Localization of receptors for natriuretic peptide and endothelin in the duct of the epididymis of the freshwater turtle.
Release_Year 2000
PMID 10753564
DOI 10.1006/gcen.1999.7445