PPIRE11179

Target Protein Information
Protein_Name Adapter molecule crk
Protein_Sequence MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS
Organism_Source Homo sapiens
Functional_Classification Src homology 3 domain
Cellular_Localization Cytoplasm
Gene_Names CRK
UniProt_ID P46108
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PRM524
Peptide_Sequence QAPELPTKTRTSY
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1491.66
Aliphatic_Index 37.69231
Aromaticity 0.07692
Average_Rotatable_Bonds 3.46154
Charge_at_pH_7 0.99861
Isoelectric_Point 9.29736
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 664.40000
X_logP_energy -8.10013
Interaction Information
Affinity KD=1.72 mM
Affinity_Assay fluorescence spectroscopy
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl.
Release_Year 2016
PMID 27332121
DOI 10.1016/j.bpj.2016.05.008