PPIRE11237

Target Protein Information
Protein_Name Alanine aminotransferase 1
Protein_Sequence MASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPFTEVIRANIGDAQAMGQRPITFLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHSLGAYSVSSGIQLIREDVARYIERRDGGIPADPNNVFLSTGASDAIVTVLKLLVAGEGHTRTGVLIPIPQYPLYSATLAELGAVQVDYYLDEERAWALDVAELHRALGQARDHCRPRALCVINPGNPTGQVQTRECIEAVIRFAFEERLFLLADEVYQDNVYAAGSQFHSFKKVLMEMGPPYAGQQELASFHSTSKGYMGECGFRGGYVEVVNMDAAVQQQMLKLMSVRLCPPVPGQALLDLVVSPPAPTDPSFAQFQAEKQAVLAELAAKAKLTEQVFNEAPGISCNPVQGAMYSFPRVQLPPRAVERAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPLEKLRLLLEKLSRFHAKFTLEYS
Organism_Source Homo sapiens
Functional_Classification transaminases
Cellular_Localization Cytoplasm
Gene_Names GPT
UniProt_ID P24298
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ALT5-8
Peptide_Sequence WHWRNPDFWYLKC
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1851.12
Aliphatic_Index 30.00000
Aromaticity 0.38462
Average_Rotatable_Bonds 3.92308
Charge_at_pH_7 1.02622
Isoelectric_Point 8.53046
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 668.32000
X_logP_energy -0.23083
Interaction Information
Affinity KD=20.1 nM
Affinity_Assay quartz crystal microbalance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Rapid development of new protein biosensors utilizing peptides obtained via phage display.
Release_Year 2011
PMID 22003385
DOI 10.1371/journal.pone.0024948