PPIRE11244

Target Protein Information
Protein_Name Centrosomal protein of 55 kDa
Protein_Sequence MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTTLLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK
Organism_Source Homo sapiens
Functional_Classification coiled-coil proteins
Cellular_Localization Cytoplasm
Gene_Names CEP55
UniProt_ID Q53EZ4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TEX14_792-804
Peptide_Sequence XAXGPPXXXYIPP
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1096.21
Aliphatic_Index 37.69231
Aromaticity 0.07692
Average_Rotatable_Bonds 1.92308
Charge_at_pH_7 -0.00287
Isoelectric_Point 6.09320
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 11
Topological_Polar_Surface_Area 397.59000
X_logP_energy -4.95660
Interaction Information
Affinity KD=300 nM
Affinity_Assay Surface plasmon resonance
PDB_ID 3WUT
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14)in forming the stable intercellular bridges of germ cells.
Release_Year 2015
PMID 26392564
DOI 10.1073/pnas.1418606112