PPIRE11250

Target Protein Information
Protein_Name Neurotensin receptor type 1
Protein_Sequence MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names NTSR1
UniProt_ID P30989
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Neurotensin
Peptide_Sequence XLYENKPRRPYIL
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification X1=pyroglutamic acid
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Pyroglutamation
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1618.90
Aliphatic_Index 90.00000
Aromaticity 0.15385
Average_Rotatable_Bonds 3.84615
Charge_at_pH_7 1.99776
Isoelectric_Point 10.00649
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 665.61000
X_logP_energy -3.70966
Interaction Information
Affinity KD=30 uM
Affinity_Assay NMR chemical shift titration
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor.
Release_Year 2013
PMID 23140271
DOI 10.1080/07391102.2012.736776