PPIRE11273

Target Protein Information
Protein_Name Adapter molecule crk
Protein_Sequence MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS
Organism_Source Homo sapiens
Functional_Classification SH3 domains
Cellular_Localization Cytoplasm
Gene_Names CRK
UniProt_ID P46108
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PRMNS1
Peptide_Sequence YGRPPLPPKQKRK
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1564.90
Aliphatic_Index 30.00000
Aromaticity 0.07692
Average_Rotatable_Bonds 3.69231
Charge_at_pH_7 4.99624
Isoelectric_Point 11.76841
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 642.54000
X_logP_energy -4.95446
Interaction Information
Affinity KD=10 nM
Affinity_Assay fluorescence spectroscopy
PDB_ID 6ATV
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Molecular Mechanisms of Tight Binding through Fuzzy Interactions.
Release_Year 2018
PMID 29590589
DOI 10.1016/j.bpj.2018.01.031