PPIRE11275

Target Protein Information
Protein_Name Tudor domain-containing protein 3
Protein_Sequence MLRLQMTDGHISCTAVEFSYMSKISLNTPPGTKVKLSGIVDIKNGFLLLNDSNTTVLGGEVEHLIEKWELQRSLSKHNRSNIGTEGGPPPFVPFGQKCVSHVQVDSRELDRRKTLQVTMPVKPTNDNDEFEKQRTAAIAEVAKSKETKTFGGGGGGARSNLNMNAAGNRNREVLQKEKSTKSEGKHEGVYRELVDEKALKHITEMGFSKEASRQALMDNGNNLEAALNVLLTSNKQKPVMGPPLRGRGKGRGRIRSEDEEDLGNARPSAPSTLFDFLESKMGTLNVEEPKSQPQQLHQGQYRSSNTEQNGVKDNNHLRHPPRNDTRQPRNEKPPRFQRDSQNSKSVLEGSGLPRNRGSERPSTSSVSEVWAEDRIKCDRPYSRYDRTKDTSYPLGSQHSDGAFKKRDNSMQSRSGKGPSFAEAKENPLPQGSVDYNNQKRGKRESQTSIPDYFYDRKSQTINNEAFSGIKIEKHFNVNTDYQNPVRSNSFIGVPNGEVEMPLKGRRIGPIKPAGPVTAVPCDDKIFYNSGPKRRSGPIKPEKILESSIPMEYAKMWKPGDECFALYWEDNKFYRAEVEALHSSGMTAVVKFIDYGNYEEVLLSNIKPIQTEAWEEEGTYDQTLEFRRGGDGQPRRSTRPTQQFYQPPRARN
Organism_Source Homo sapiens
Functional_Classification Tudor domain-containing proteins
Cellular_Localization Nucleus
Gene_Names TDRD3
UniProt_ID Q9H7E2
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name aDMA-CTD peptide
Peptide_Sequence YSPSSPRYTPQSP
Peptide_Length 13
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification R7=asymmetric dimethylation
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1466.57
Aliphatic_Index 0.00000
Aromaticity 0.15385
Average_Rotatable_Bonds 2.84615
Charge_at_pH_7 0.99628
Isoelectric_Point 9.17163
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 623.96000
X_logP_energy -8.98393
Interaction Information
Affinity KD=770 uM
Affinity_Assay NMR titration
PDB_ID 2LTO
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Recognition of asymmetrically dimethylated arginine by TDRD3.
Release_Year 2012
PMID 23066109
DOI 10.1093/nar/gks929