PPIRE11279

Target Protein Information
Protein_Name Phospholipid hydroperoxide glutathione peroxidase GPX4
Protein_Sequence MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
Organism_Source Homo sapiens
Functional_Classification peroxidases
Cellular_Localization Cytoplasm
Gene_Names GPX4
UniProt_ID P36969
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name GXpep-1
Peptide_Sequence CRVDLQGWRRCRR
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C1<->C11; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1704.01
Aliphatic_Index 52.30769
Aromaticity 0.07692
Average_Rotatable_Bonds 4.38462
Charge_at_pH_7 3.87446
Isoelectric_Point 11.89865
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 818.20000
X_logP_energy -8.81045
Interaction Information
Affinity KD=1.8 uM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis.
Release_Year 2016
PMID 27836545
DOI 10.1016/j.bbrc.2016.11.035