PPIRE11304

Target Protein Information
Protein_Name Replication protein A 70 kDa DNA-binding subunit
Protein_Sequence MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYREYGRRLVMSIRRSALM
Organism_Source Homo sapiens
Functional_Classification single-stranded DNA-binding proteins
Cellular_Localization Nucleus
Gene_Names RPA1
UniProt_ID P27694
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name peptide-39
Peptide_Sequence DFTAXDLEEXXAL
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(=O)O
Chemical_Modification X5=alpha-(4-pentenyl)alanine; X9=alpha-(4-pentenyl)alanine; X11=3,4-dichlorophenylalanine
Cyclization_Method Side chain-side chain cyclization; X5<->X9; other bonds
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1294.34
Aliphatic_Index 75.38462
Aromaticity 0.07692
Average_Rotatable_Bonds 3.23077
Charge_at_pH_7 -3.99757
Isoelectric_Point 3.29497
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 581.95000
X_logP_energy -6.45540
Interaction Information
Affinity KD=0.042 uM
Affinity_Assay Fluorescence Polarization
PDB_ID 4NB3
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A.
Release_Year 2014
PMID 24491171
DOI 10.1021/jm401730y