PPIRE11315
Target Protein Information
| Protein_Name | Neuronal acetylcholine receptor subunit alpha-4 |
|---|---|
| Protein_Sequence | MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPSPTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAVETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQEAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKEPSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAAC |
| Organism_Source | Rattus norvegicus |
| Functional_Classification | nicotinic acetylcholine receptors |
| Cellular_Localization | Plasma membrane |
| Gene_Names | Chrna4 |
| UniProt_ID | P09483 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | alpha-Conotoxin BuIA |
|---|---|
| Peptide_Sequence | GCCSTPPCAVLYC |
| Peptide_Length | 13 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CN)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain cyclization; C2<->C8; disulfide bond; C3<->C13; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1316.59 |
|---|---|
| Aliphatic_Index | 60.00000 |
| Aromaticity | 0.07692 |
| Average_Rotatable_Bonds | 2.61538 |
| Charge_at_pH_7 | -0.25076 |
| Isoelectric_Point | 5.70715 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 21 |
| Number_of_Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 455.63000 |
| X_logP_energy | -5.37770 |
Interaction Information
| Affinity | IC50=10400 nM |
|---|---|
| Affinity_Assay | two-electrode voltage clamp |
| PDB_ID | None |
| Type | Ion channel modulator |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors. |
| Release_Year | 2005 |
| PMID | 15520009 |
| DOI | 10.1074/jbc.M406281200 |