PPIRE11317

Target Protein Information
Protein_Name Neuronal acetylcholine receptor subunit alpha-2
Protein_Sequence MTLSHSALQFWTHLYLWCLLLVPAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPDLKLSPSYHWLETNMDAGEREETEEEEEEEDENICVCAGLPDSSMGVLYGHGGLHLRAMEPETKTPSQASEILLSPQIQKALEGVHYIADRLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
Organism_Source Rattus norvegicus
Functional_Classification nicotinic acetylcholine receptors
Cellular_Localization Plasma membrane
Gene_Names Chrna2
UniProt_ID P12389
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name alpha-Conotoxin BuIA
Peptide_Sequence GCCSTPPCAVLYC
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CN)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain cyclization; C2<->C8; disulfide bond; C3<->C13; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1316.59
Aliphatic_Index 60.00000
Aromaticity 0.07692
Average_Rotatable_Bonds 2.61538
Charge_at_pH_7 -0.25076
Isoelectric_Point 5.70715
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 455.63000
X_logP_energy -5.37770
Interaction Information
Affinity IC50=121 nM
Affinity_Assay two-electrode voltage clamp
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title Alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors.
Release_Year 2005
PMID 15520009
DOI 10.1074/jbc.M406281200