PPIRE11332

Target Protein Information
Protein_Name Tumor necrosis factor ligand superfamily member 13
Protein_Sequence MPASSPGHMGGSVREPALSVALWLSWGAVLGAVTCAVALLIQQTELQSLRREVSRLQRSGGPSQKQGERPWQSLWEQSPDVLEAWKDGAKSRRRRAVLTQKHKKKHSVLHLVPVNITSKADSDVTEVMWQPVLRRGRGLEAQGDIVRVWDTGIYLLYSQVLFHDVTFTMGQVVSREGQGRRETLFRCIRSMPSDPDRAYNSCYSAGVFHLHQGDIITVKIPRANAKLSLSPHGTFLGFVKL
Organism_Source Mus musculus
Functional_Classification TNF ligand superfamily
Cellular_Localization Extracellular
Gene_Names Tnfsf13
UniProt_ID Q9D777
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 2.12
Peptide_Sequence TACSWWLPEACEV
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C3<->C11; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1494.70
Aliphatic_Index 67.69231
Aromaticity 0.15385
Average_Rotatable_Bonds 3.15385
Charge_at_pH_7 -2.12241
Isoelectric_Point 3.61367
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 550.37000
X_logP_energy -3.12570
Interaction Information
Affinity IC50=0.49 uM
Affinity_Assay BIAcore competition assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage display.
Release_Year 2010
PMID 19945466
DOI 10.1016/j.jmb.2009.11.041