PPIRE11353
Target Protein Information
| Protein_Name | Alpha-glucosidase MAL62 |
|---|---|
| Protein_Sequence | MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGREIMRVGEVAHGSDNALYTSAARYEVSEVFSFTHVEVGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFFLNESFEQGINVEQESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNFSGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK |
| Organism_Source | Saccharomyces cerevisiae |
| Functional_Classification | glycosidases |
| Cellular_Localization | Extracellular |
| Gene_Names | MAL62 |
| UniProt_ID | P07265 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | SP-GI |
|---|---|
| Peptide_Sequence | SEDSSEVDIDLGN |
| Peptide_Length | 13 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 1379.35 |
|---|---|
| Aliphatic_Index | 82.30769 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.61538 |
| Charge_at_pH_7 | -4.99713 |
| Isoelectric_Point | 3.19606 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 23 |
| Number_of_Hydrogen_Bond_Donors | 23 |
| Topological_Polar_Surface_Area | 702.80000 |
| X_logP_energy | -10.39850 |
Interaction Information
| Affinity | IC50=2.9 uM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Investigating inhibitory activity of novel synthetic sericin peptide on Alpha-D-glucosidase: kinetics and interaction mechanism study using a docking simulation. |
| Release_Year | 2018 |
| PMID | 28799644 |
| DOI | 10.1002/jsfa.8620 |