PPIRE11357
Target Protein Information
| Protein_Name | Tudor domain-containing protein 1 |
|---|---|
| Protein_Sequence | MMPRNNLEASTCKMAEPFNFEKKESKPPPQDPLRSPVAQHNHPTFRLKSPENGNTKNNFLLCEQNKQYLASQEDSSVVSSNPAVVNGEVGGSKGDRKPPPTGNPVSPLSLGNSSPPNQVKTKPSSNVTPEKSKKSHKLFENALSVNNPALFNSLGPPLRSTTCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSSHSTICRPVQQSLNKLEDNKSPFETKAIEVKSEVDCPPGVTKEITAGAERVMFSDLRSLQLKKTMEIKGTVTEFKHPSNFYIQLYSSEVLENMNQLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSEGCVAAVKALLFEQFCSVKVMDILEEEVLTCAVDLVLQSSGKQLDHVLVEMGYGVKPGEQSSTEQSVDHSALEDVGRVTVESKIVTDRNALIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEAVCVMKEMVQNRMVTVRVVGMLGTRALVELIDKSVAPHVSASKALIDSGFAIKEKDVADKGSSMHTASVPLAIEGPAEALEWTWVEFTVDETVDVVVCMMYSPGEFYCHFLKDDALEKLDDLNQSLADYCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKHWTKEATARFQACVVGLKLQARVVEITANGVGVELTDLSTPYPKIISDVLIREQLVLRCGSPQDSLMSRPANQHKQIDSHRVQASPSAEQWKTMELPVNKTIAANVLEIISPALFYAIPSEMSENQEKLCVLAAELLEHCNAQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEGPMELNGSCSQLVMELLRNAMLNQSVVLSVKAISKNVHAVSVEKCSENGMINIAENLVMCGLAENLTSKRKSASTKEIPHSRDCCCTELQKQIEKHEQILLFLLNNPTNQSKFTEMKKLLRS |
| Organism_Source | Mus musculus |
| Functional_Classification | Tudor domain-containing proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | Tdrd1 |
| UniProt_ID | Q99MV1 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | MILI R45me2 |
|---|---|
| Peptide_Sequence | GRAGPAGXGLVFR |
| Peptide_Length | 13 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C |
| Chemical_Modification | X8=symmetrically dimethylated arginine |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1214.39 |
|---|---|
| Aliphatic_Index | 67.69231 |
| Aromaticity | 0.07692 |
| Average_Rotatable_Bonds | 2.84615 |
| Charge_at_pH_7 | 1.99798 |
| Isoelectric_Point | 12.50011 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 16 |
| Number_of_Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 527.53000 |
| X_logP_energy | -6.60976 |
Interaction Information
| Affinity | KD=172 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | 4B9W |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors. |
| Release_Year | 2012 |
| PMID | 22996915 |
| DOI | 10.1261/rna.034181.112 |