PPIRE11361

Target Protein Information
Protein_Name Tudor domain-containing protein 1
Protein_Sequence MMPRNNLEASTCKMAEPFNFEKKESKPPPQDPLRSPVAQHNHPTFRLKSPENGNTKNNFLLCEQNKQYLASQEDSSVVSSNPAVVNGEVGGSKGDRKPPPTGNPVSPLSLGNSSPPNQVKTKPSSNVTPEKSKKSHKLFENALSVNNPALFNSLGPPLRSTTCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSSHSTICRPVQQSLNKLEDNKSPFETKAIEVKSEVDCPPGVTKEITAGAERVMFSDLRSLQLKKTMEIKGTVTEFKHPSNFYIQLYSSEVLENMNQLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSEGCVAAVKALLFEQFCSVKVMDILEEEVLTCAVDLVLQSSGKQLDHVLVEMGYGVKPGEQSSTEQSVDHSALEDVGRVTVESKIVTDRNALIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEAVCVMKEMVQNRMVTVRVVGMLGTRALVELIDKSVAPHVSASKALIDSGFAIKEKDVADKGSSMHTASVPLAIEGPAEALEWTWVEFTVDETVDVVVCMMYSPGEFYCHFLKDDALEKLDDLNQSLADYCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKHWTKEATARFQACVVGLKLQARVVEITANGVGVELTDLSTPYPKIISDVLIREQLVLRCGSPQDSLMSRPANQHKQIDSHRVQASPSAEQWKTMELPVNKTIAANVLEIISPALFYAIPSEMSENQEKLCVLAAELLEHCNAQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEGPMELNGSCSQLVMELLRNAMLNQSVVLSVKAISKNVHAVSVEKCSENGMINIAENLVMCGLAENLTSKRKSASTKEIPHSRDCCCTELQKQIEKHEQILLFLLNNPTNQSKFTEMKKLLRS
Organism_Source Mus musculus
Functional_Classification Tudor domain-containing proteins
Cellular_Localization Cytoplasm
Gene_Names Tdrd1
UniProt_ID Q99MV1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name MILI R83me2
Peptide_Sequence MGLDTAFXPPSKR
Peptide_Length 13
Peptide_SMILES CSCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O
Chemical_Modification X8=symmetrically dimethylated arginine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1376.59
Aliphatic_Index 37.69231
Aromaticity 0.07692
Average_Rotatable_Bonds 3.23077
Charge_at_pH_7 0.99813
Isoelectric_Point 9.69502
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 560.62000
X_logP_energy -6.20703
Interaction Information
Affinity KD=245 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors.
Release_Year 2012
PMID 22996915
DOI 10.1261/rna.034181.112