PPIRE11364

Target Protein Information
Protein_Name Importin subunit alpha-5
Protein_Sequence MSTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQINNMEMAPGGVITSDMTDMIFSNSPEQQLSATQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLNCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENILRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLSQQQYIFQQCEAPMEGFQL
Organism_Source Mus musculus
Functional_Classification nuclear transporters
Cellular_Localization Cytoplasm
Gene_Names Kpna1
UniProt_ID Q60960
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pol mu NLS(Met1 included)
Peptide_Sequence MLPKRRRARVGGK
Peptide_Length 13
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification FITC
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1524.90
Aliphatic_Index 60.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.15385
Charge_at_pH_7 5.99738
Isoelectric_Point 12.98470
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 703.37000
X_logP_energy -7.22892
Interaction Information
Affinity KD=11.2 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Variations in nuclear localization strategies among pol X family enzymes.
Release_Year 2018
PMID 29931796
DOI 10.1111/tra.12600