PPIRE11365

Target Protein Information
Protein_Name Protein tudor
Protein_Sequence MNGQARIALPSKVDLYITHVDHVGPYLKVYGHVNRDAASLISERIRNLLPTCFAIEPSWSVERQQALLIPGTFCIFKNINGPAPGDVEYRRIRVVSADLEGQSMRAEIDFVDFGYKRTVDSHDLMFPKQPKLLQNIPLHCFQYIVLGICSEWDQTDLAEVRRLVVNQIVKITVEPTQICDQKFASLRWKDFELNEFLVQQKQIGVSVDKQLMMDHCKKLWKDNPQSPVTEYNNNSIHNSKTPMEIAREQLAVRQSLAARLDAQRSVQVTPSRPLNADAPDYTPKHLPLVNVTNVQVQMPGLNNTQKPVFVSTNPYNRANYQPAVPAAQPYVPKANPRSQYTYYNVRMNKPINAMPPPAGPHVPIQHFNQQANNVSLSYVPARFTPPPTPSIAQHQIPIPAFRTTSLTVGLTYDVVISYVENGPYLFWVHLKSSDHDLSTMMGQIERTKLKALAQAPELGTACVARFSEDGHLYRAMVCAVYAQRYRVVYVDYGNSELLSASDLFQIPPELLEIKPFAFRFALAGTKEIEPIDDSMKRIFKKSAIYRNFELTVQAPESVGSMQTCHLNQNGTNMLELLRQLKNSRQSYKKAEQLENDDAVEIRFIDSPSNFYVQKVANIGKFEQLMDEMFSYYNANQRVPDQLILGAPCIVKCDQEWYRAEILRVDDSVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKGFENSELSEDKITDQFEMLAEESNIRRRTFSVRIFRIEPDGLNVVNLLAKNLNVMKKLYKLSMPFEQYLSLEKGQFNANNTRAESVISSELNKSHILNSTSIGETENRLQEQEKEQQQKKVDVRQQQLAVEIPQAVKSVSGSKNSTDWDKRSSTSAGSKDSKRQQQQQIQRIDRHLDFSCETQSTGSYSSGMSSPRKGNRQQNGRTPIQSPRHNEKQEAKKNARFSNSESPRRSRDGQQGNQRSQNAPQGYAQKPQRQKSTLDGNISSKRSSGVGSDIASSSSESVAAAKPEKYVSLDKPYALQEMKTPSKEAASLSWWLSPFQFYIVPKSVSAKYDNIMRDMREFYRQKQHQPLQLKVGSTVVVRQRKDNAILRATVTACNHMMRKYRVFCVDTGSLITVTSEDIWQLEQRFADPPCMAHRCSFHSVVTNYDPLYIVDRMETFVPVNAKVDCEFVSKEKSNQGSNTSSTCSYTVNIFVNGASLRDMLVKAEFLTEVAPEIRVNLLAGQQIRGKFTSIRDMTSFKVQFDYGNNVNFLCTYDDAKFVKSNPNLARRFKEFYEGKSFALNVKNVCENNIVHLRPVMPLFMEDRRSFICPYPVVLSSFQALVVYTAKPYRVYVQPQAIVPSMQTLLDNMYEHYKAKGDSLKKFDVGQICAVRSSDGNWYRARISGKDSNAACFEVFYIDYGNTEEIKRDDIKALDAKFYEHASGFAVEINLPIGRPSNDTKLKARISEILEEKVVTIKSIEVRRSHLIADVILENNQSVIDLLKAEKLVPGKDLDYMRKQMEKGKSRTYEYIETVDLTLDEEEDKGRKETVSKSGSANASPKKKQHNDKDREPKKSKPAEPARTVAPQPVALKTPSPVPAEPAPVPKPATPVPEVVEVPEINPTVREAAAESKQAPAQEDPYKDLDCVVLSHCDNPAQFYVHPIDQLSKLNQLHENLQIVSPSLPQLMNVVNGADCVSMYSVDKCWYRAKIIDAELMVLLFIDYGNTDCVSDATDIKESMWSHIEPFCLPCALPIRPKGTADWVDAANGIFNESYSKVPRLEYLTQGDHYTTSYVNMYIDGEDVAKKLIADGFARPLEYLASGCSCYISHVNGICDFFIQLERDSKALELIELYLRKKDTLKPLEGFEKGLIVAALFEDDELWYRAQLQKELPDSRYEVLFIDYGNTSTTSKCLMLSEEIASLPSLSKKCSLQLPDAYISWSPEAEAKFAELTGEGELVFTTQLLKPGQDHVTIDLLLDGENIIDRLLPLCQRKEPKEASKESLAVTTKAIITHVENTSRIYLQFSEKDSLMDIICEKLNGSKLQPKTEKAAVDDMCVVQFADDLEFYRSRILEVLEDDQYKVILIDYGNTTVVDKLYELPQEFTLIKPVAEICSMEPSAIFEKNKALTLTTFDALLDSCKGVVAVEFVNKSASPPVVRLTTKDKRSLKIYEHLQKLVQAELKLIQKRNENSECIISYGNSPKSFYVQMKHNSADLDLIVKTLQSLKKEKLKKLIDPTTNSNGVCYSQEDACYYRCSIKSVLDPSQGFEVFLLDYGNTLVVPEVWQLPQEIEPIPSLALHCQLSKIPMDVSDEKLEEAFAALLEQHFGELYEITTQPNEDETKPLIAELRINYKDFVQELVSTVTGVQKPLEAELHNCVVVQFDGPMSFYVQMESDVPALEQMTDKLLDAEQDLPAFSDLKEGALCVAQFPEDEVFYRAQIRKVLDDGKCEVHFIDFGNNAVTQQFRQLPEELAKPARYSRHCELDASTISKCDAALLQSFIDTRFSETFQVEILATKGTGTHVVRLFYQSKNISEKLQECQ
Organism_Source Drosophila melanogaster
Functional_Classification Tudor domain proteins
Cellular_Localization Cytoplasm
Gene_Names tud
UniProt_ID P25823
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Aub R11(me2s)
Peptide_Sequence NPVIAXGRGRGRK
Peptide_Length 13
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(N)=O)C(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification X6=symmetric dimethylarginine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1337.55
Aliphatic_Index 60.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.46154
Charge_at_pH_7 3.99768
Isoelectric_Point 12.80743
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 658.54000
X_logP_energy -9.23609
Interaction Information
Affinity KD=71 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for methylarginine-dependent recognition of Aubergine by Tudor.
Release_Year 2010
PMID 20713507
DOI 10.1101/gad.1956010