PPIRE11395

Target Protein Information
Protein_Name WD repeat-containing protein 5
Protein_Sequence MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Organism_Source Homo sapiens
Functional_Classification WD40-repeat protein
Cellular_Localization Nucleus
Gene_Names WDR5
UniProt_ID P61964
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Histone H3 K4me2 peptide
Peptide_Sequence ARTKQTARKSTGGK
Peptide_Length 14
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification K4=dimethylation
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1489.70
Aliphatic_Index 14.28571
Aromaticity 0.00000
Average_Rotatable_Bonds 3.85714
Charge_at_pH_7 4.99709
Isoelectric_Point 12.54608
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 767.49000
X_logP_energy -12.68296
Interaction Information
Affinity KD=1.02 mM
Affinity_Assay Surface plasmon resonance
PDB_ID 2H6N
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.
Release_Year 2006
PMID 16829959
DOI 10.1038/nsmb1119