PPIRE11397

Target Protein Information
Protein_Name Importin subunit alpha-1
Protein_Sequence MSTNENANLPAARLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASLNLIEKYFSVEEEEDQNVVPETTSEGFAFQVQDGAPGTFNF
Organism_Source Mus musculus
Functional_Classification nuclear transport receptors
Cellular_Localization Cytoplasm
Gene_Names Kpna2
UniProt_ID P52293
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name NP ncNLS
Peptide_Sequence ASQGTKRSYEQMET
Peptide_Length 14
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1615.74
Aliphatic_Index 7.14286
Aromaticity 0.07143
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 0.00039
Isoelectric_Point 6.52530
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 791.47000
X_logP_energy -11.54753
Interaction Information
Affinity KD=1.7 uM
Affinity_Assay solid phase binding assay
PDB_ID 4ZDU
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structure of importin-Alpha bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein.
Release_Year 2015
PMID 26456934
DOI 10.1038/srep15055