PPIRE11398
Target Protein Information
| Protein_Name | Baculoviral IAP repeat-containing protein 5 |
|---|---|
| Protein_Sequence | MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD |
| Organism_Source | Homo sapiens |
| Functional_Classification | BIR domain proteins |
| Cellular_Localization | Nucleus |
| Gene_Names | BIRC5 |
| UniProt_ID | O15392 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | SmacN(1-15) |
|---|---|
| Peptide_Sequence | AVPIXXXXXXXXXX |
| Peptide_Length | 14 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 969.02 |
|---|---|
| Aliphatic_Index | 55.71429 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.07143 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 15 |
| Number_of_Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 432.83000 |
| X_logP_energy | -8.75710 |
Interaction Information
| Affinity | KD=121 mM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | 3UIH |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin. |
| Release_Year | 2012 |
| PMID | 22244766 |
| DOI | 10.1016/j.str.2011.12.001 |