PPIRE11400

Target Protein Information
Protein_Name cAMP-dependent protein kinase catalytic subunit alpha
Protein_Sequence MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
Organism_Source Bos taurus
Functional_Classification kinases
Cellular_Localization Cytoplasm
Gene_Names PRKACA
UniProt_ID P00517
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Tat-peptide48-60
Peptide_Sequence CGRKKRRQRRRPPQ
Peptide_Length 14
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)CNC(=O)[C@@H](N)CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1822.17
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.57143
Charge_at_pH_7 7.93540
Isoelectric_Point 12.80742
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 36
Topological_Polar_Surface_Area 933.66000
X_logP_energy -12.35708
Interaction Information
Affinity IC50=1.2 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition.
Release_Year 2010
PMID 20433920
DOI 10.1016/j.ejps.2010.04.013