PPIRE11415

Target Protein Information
Protein_Name None
Protein_Sequence WTAADMAAQITRRKWEQAGAAERDRAYLEGECVEWLRRYLKNGNATLLRTDPPKAHVTHHRRPEGDVTLRCWALGFYPADITLTWQLNGEELTQEMELVETRPAGDGTFQKWASVVVPLGKELKYTCHVEHEGPEPLTLRWGKEEPPSSTKTNTVIIAVPVVLGAVVILGAVMAFVMKRRRNTGGKGGDYALAPGSQSSDMSLPDCKV
Organism_Source Mus musculus
Functional_Classification MHC class I
Cellular_Localization Plasma membrane
Gene_Names H2-D1
UniProt_ID Q31154
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DAN-PbCS
Peptide_Sequence YIPSAEKI
Peptide_Length 8
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)CC)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Dansylation
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 920.07
Aliphatic_Index 110.00000
Aromaticity 0.12500
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 -0.00139
Isoelectric_Point 6.40200
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 362.01000
X_logP_energy -1.65540
Interaction Information
Affinity Ka=1.64E+06 1/M
Affinity_Assay fluorescence spectroscopy
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Real-time measurement of antigenic peptide binding to empty and preloaded single-chain major histocompatibility complex class I molecules.
Release_Year 1993
PMID 8477806
DOI 10.1002/eji.1830230521