PPIRE11442

Target Protein Information
Protein_Name Importin subunit alpha-5
Protein_Sequence MSTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQINNMEMAPGGVITSDMTDMIFSNSPEQQLSATQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLNCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENILRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLSQQQYIFQQCEAPMEGFQL
Organism_Source Mus musculus
Functional_Classification nuclear import receptors
Cellular_Localization Cytoplasm
Gene_Names Kpna1
UniProt_ID Q60960
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Tat:NLS/CPP
Peptide_Sequence GRKKRRQRRRAPQN
Peptide_Length 14
Peptide_SMILES C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1807.10
Aliphatic_Index 7.14286
Aromaticity 0.00000
Average_Rotatable_Bonds 4.71429
Charge_at_pH_7 7.99737
Isoelectric_Point 13.20310
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 37
Topological_Polar_Surface_Area 985.54000
X_logP_energy -13.89778
Interaction Information
Affinity KD=1.2 uM
Affinity_Assay GST-pulldown assay
PDB_ID 5SVZ
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural Basis for Importin-Alpha Binding of the Human Immunodeficiency Virus Tat.
Release_Year 2017
PMID 28490747
DOI 10.1038/s41598-017-01853-7