PPIRE11446

Target Protein Information
Protein_Name Interleukin-5 receptor subunit alpha
Protein_Sequence MIIVAHVLLILLGATEILQADLLPDEKISLLPPVNFTIKVTGLAQVLLQWKPNPDQEQRNVNLEYQVKINAPKEDDYETRITESKCVTILHKGFSASVRTILQNDHSLLASSWASAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQYFLYYRYGSWTEECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPFDQLFALHAIDQINPPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQIEKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWSQPIYVGNDEHKPLREWFVIVIMATICFILLILSLICKICHLWIKLFPPIPAPKSNIKDLFVTTNYEKAGSSETEIEVICYIEKPGVETLEDSVF
Organism_Source Homo sapiens
Functional_Classification cytokine receptors
Cellular_Localization Plasma membrane
Gene_Names IL5RA
UniProt_ID Q01344
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AF17517
Peptide_Sequence GYVCVEWARCPTCK
Peptide_Length 14
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1614.92
Aliphatic_Index 48.57143
Aromaticity 0.14286
Average_Rotatable_Bonds 3.35714
Charge_at_pH_7 0.81269
Isoelectric_Point 8.04081
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 614.30000
X_logP_energy -4.73023
Interaction Information
Affinity IC50=1.9 nM
Affinity_Assay competitive radioligand binding assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Modified peptide antagonists of interleukin 5 exhibit extended in vivo persistence but restricted species specificity.
Release_Year 2001
PMID 11509004
DOI 10.1006/cyto.2001.0886