PPIRE11456

Target Protein Information
Protein_Name None
Protein_Sequence WTAADMAAQITRRKWEQAGAAERDRAYLEGECVEWLRRYLKNGNATLLRTDPPKAHVTHHRRPEGDVTLRCWALGFYPADITLTWQLNGEELTQEMELVETRPAGDGTFQKWASVVVPLGKELKYTCHVEHEGPEPLTLRWGKEEPPSSTKTNTVIIAVPVVLGAVVILGAVMAFVMKRRRNTGGKGGDYALAPGSQSSDMSLPDCKV
Organism_Source Mus musculus
Functional_Classification MHC class I
Cellular_Localization Plasma membrane
Gene_Names H2-D1
UniProt_ID Q31154
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DAN-HLA-Cw3
Peptide_Sequence RYLKNGKETL
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Dansylation
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1221.42
Aliphatic_Index 78.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 4.30000
Charge_at_pH_7 1.99832
Isoelectric_Point 10.24366
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 560.01000
X_logP_energy -4.92433
Interaction Information
Affinity Ka=1.10E+06 1/M
Affinity_Assay fluorescence spectroscopy
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Real-time measurement of antigenic peptide binding to empty and preloaded single-chain major histocompatibility complex class I molecules.
Release_Year 1993
PMID 8477806
DOI 10.1002/eji.1830230521