PPIRE11465

Target Protein Information
Protein_Name Guanine nucleotide-binding protein G(i)subunit alpha-1
Protein_Sequence MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Organism_Source Bos taurus
Functional_Classification GTP-binding proteins/GTPases
Cellular_Localization Plasma membrane
Gene_Names GNAI1
UniProt_ID P63097
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Mastoparan
Peptide_Sequence INLKALAALAKKIL
Peptide_Length 14
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1479.91
Aliphatic_Index 195.71429
Aromaticity 0.00000
Average_Rotatable_Bonds 3.78571
Charge_at_pH_7 2.99710
Isoelectric_Point 11.10307
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 562.77000
X_logP_energy -1.68070
Interaction Information
Affinity IC50=0.75 uM
Affinity_Assay in vitro Golgi transport assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title The G protein-activating peptide, mastoparan, and the synthetic NH2-terminal ARF peptide, ARFp13, inhibit in vitro Golgi transport by irreversibly damaging membranes.
Release_Year 1994
PMID 7806562
DOI 10.1083/jcb.127.6.1815