PPIRE11487

Target Protein Information
Protein_Name DNA excision repair protein ERCC-1
Protein_Sequence MDPGKDKEGVPQPSGPPARKKFVIPLDEDEVPPGVAKPLFRSTQSLPTVDTSAQAAPQTYAEYAISQPLEGAGATCPTGSEPLAGETPNQALKPGAKSNSIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDPQQALKELAKMCILADCTLILAWSPEEAGRYLETYKAYEQKPADLLMEKLEQDFVSRVTECLTTVKSVNKTDSQTLLTTFGSLEQLIAASREDLALCPGLGPQKARRLFDVLHEPFLKVP
Organism_Source Homo sapiens
Functional_Classification nucleases
Cellular_Localization Nucleus
Gene_Names ERCC1
UniProt_ID P07992
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name XPA67-80
Peptide_Sequence KIIDTGGGFILEEE
Peptide_Length 14
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1520.70
Aliphatic_Index 111.42857
Aromaticity 0.07143
Average_Rotatable_Bonds 3.78571
Charge_at_pH_7 -2.99654
Isoelectric_Point 3.77824
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 637.07000
X_logP_energy -4.39910
Interaction Information
Affinity KD=0.78 mM
Affinity_Assay Fluorescence Polarization
PDB_ID 2JNW
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA.
Release_Year 2007
PMID 17948053
DOI 10.1038/sj.emboj.7601894