PPIRE11535

Target Protein Information
Protein_Name Proteasomal ubiquitin receptor ADRM1
Protein_Sequence MTTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD
Organism_Source Homo sapiens
Functional_Classification ubiquitin receptors
Cellular_Localization Cytoplasm
Gene_Names ADRM1
UniProt_ID Q16186
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name RPN2_940-953
Peptide_Sequence PQEPEPPEPFEYID
Peptide_Length 14
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification fluorescein
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1686.79
Aliphatic_Index 27.85714
Aromaticity 0.14286
Average_Rotatable_Bonds 3.28571
Charge_at_pH_7 -4.99532
Isoelectric_Point 3.25717
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 642.29000
X_logP_energy -3.41330
Interaction Information
Affinity Ki=7.1 nM
Affinity_Assay Fluorescence Polarization
PDB_ID 5V1Y
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism.
Release_Year 2017
PMID 28442575
DOI 10.1074/jbc.M117.785287