PPIRE11536

Target Protein Information
Protein_Name 14-3-3 protein zeta/delta
Protein_Sequence MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
Organism_Source Homo sapiens
Functional_Classification scaffold proteins
Cellular_Localization Cytoplasm
Gene_Names YWHAZ
UniProt_ID P63104
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SOS1pSer1161
Peptide_Sequence PRRRPEXSAPAESS
Peptide_Length 14
Peptide_SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification X7=phosphoserine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1496.60
Aliphatic_Index 14.28571
Aromaticity 0.00000
Average_Rotatable_Bonds 3.28571
Charge_at_pH_7 1.00152
Isoelectric_Point 10.30864
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 731.04000
X_logP_energy -11.69469
Interaction Information
Affinity KD=4.06 uM
Affinity_Assay Fluorescence Polarization
PDB_ID 6F08
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural characterization of 14-3-3Zeta in complex with the human Son of sevenless homolog 1 (SOS1).
Release_Year 2018
PMID 29408703
DOI 10.1016/j.jsb.2018.01.011