PPIRE11537

Target Protein Information
Protein_Name Transcriptional enhancer factor TEF-3
Protein_Sequence MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE
Organism_Source Homo sapiens
Functional_Classification TEA domain transcription factors
Cellular_Localization Nucleus
Gene_Names TEAD4
UniProt_ID Q15561
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name peptide 8
Peptide_Sequence PXRLRKXPDSXKEP
Peptide_Length 14
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification X2=6-chlorotryptophan; X7=3-cyclobutylalanine; X12=1-naphthylalanine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1493.69
Aliphatic_Index 27.85714
Aromaticity 0.00000
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 1.99961
Isoelectric_Point 10.77375
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 680.72000
X_logP_energy -8.80556
Interaction Information
Affinity IC50=45 nM
Affinity_Assay TR-FRET assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence.
Release_Year 2019
PMID 31235263
DOI 10.1016/j.bmcl.2019.06.022