PPIRE11544

Target Protein Information
Protein_Name Proteasomal ubiquitin receptor ADRM1
Protein_Sequence MTTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD
Organism_Source Homo sapiens
Functional_Classification ubiquitin receptor
Cellular_Localization Cytoplasm
Gene_Names ADRM1
UniProt_ID Q16186
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name hRpn2(940-953)
Peptide_Sequence QEPEPPEPFEYIDD
Peptide_Length 14
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1704.76
Aliphatic_Index 27.85714
Aromaticity 0.14286
Average_Rotatable_Bonds 3.42857
Charge_at_pH_7 -5.99487
Isoelectric_Point 3.16720
Number_of_Hydrogen_Bond_Acceptors 23
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 693.58000
X_logP_energy -4.36330
Interaction Information
Affinity KD=14.7 nM
Affinity_Assay Fluorescence Polarization
PDB_ID 2NBK
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.
Release_Year 2017
PMID 28598414
DOI 10.1038/ncomms15540