PPIRE11560

Target Protein Information
Protein_Name Guanine nucleotide-binding protein G(o)subunit alpha
Protein_Sequence MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSPELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGSNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
Organism_Source Bos taurus
Functional_Classification GTPases
Cellular_Localization Plasma membrane
Gene_Names GNAO1
UniProt_ID P08239
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide Q
Peptide_Sequence RWRGRQNREKRFTC
Peptide_Length 14
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1893.16
Aliphatic_Index 0.00000
Aromaticity 0.14286
Average_Rotatable_Bonds 4.64286
Charge_at_pH_7 4.93747
Isoelectric_Point 12.33428
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 37
Topological_Polar_Surface_Area 936.64000
X_logP_energy -10.93955
Interaction Information
Affinity IC50=15 uM
Affinity_Assay photoaffinity cross-linking
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Coupling an alpha 2-adrenergic receptor peptide to G-protein: a new photolabeling agent
Release_Year 1994
PMID 7984502
DOI 10.1016/0196-9781(94)90038-8