PPIRE11608

Target Protein Information
Protein_Name WD repeat-containing protein 5
Protein_Sequence MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Organism_Source Mus musculus
Functional_Classification WD40 repeat protein
Cellular_Localization Nucleus
Gene_Names Wdr5
UniProt_ID P61965
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name RbBP5(369-381)
Peptide_Sequence YAAEDEEVDVTSVD
Peptide_Length 14
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1541.54
Aliphatic_Index 76.42857
Aromaticity 0.07143
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 -5.99620
Isoelectric_Point 3.14100
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 726.11000
X_logP_energy -7.95160
Interaction Information
Affinity KD=5.6 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2XL2
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1.
Release_Year 2010
PMID 20716525
DOI 10.1074/jbc.M110.159921