PPIRE11695

Target Protein Information
Protein_Name Peroxisome proliferator-activated receptor gamma
Protein_Sequence MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Organism_Source Homo sapiens
Functional_Classification nuclear receptor
Cellular_Localization Nucleus
Gene_Names PPARG
UniProt_ID P37231
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PGC-1alpha ID1 motif
Peptide_Sequence AEEPSLLKKLLLAPA
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1592.94
Aliphatic_Index 150.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.46667
Charge_at_pH_7 0.00094
Isoelectric_Point 6.53076
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 600.01000
X_logP_energy -2.53200
Interaction Information
Affinity IC50=1.7 uM
Affinity_Assay ELISA
PDB_ID 3CS8
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Structural and biochemical basis for the binding selectivity of peroxisome proliferator-activated receptor gamma to PGC-1alpha.
Release_Year 2008
PMID 18469005
DOI 10.1074/jbc.M802040200