PPIRE11763

Target Protein Information
Protein_Name Chromobox protein homolog 3
Protein_Sequence MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKDGTKRKSLSDSESDDSKSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTWHSCPEDEAQ
Organism_Source Homo sapiens
Functional_Classification reader domains
Cellular_Localization Nucleus
Gene_Names CBX3
UniProt_ID Q13185
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3K9me3
Peptide_Sequence ARTKQTARKSTGGKA
Peptide_Length 15
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification K9=trimethyllysine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Tamra
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1560.78
Aliphatic_Index 20.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.73333
Charge_at_pH_7 4.99709
Isoelectric_Point 12.54608
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 30
Topological_Polar_Surface_Area 796.59000
X_logP_energy -13.17826
Interaction Information
Affinity KD=1 mM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Engineering Methyllysine Writers and Readers for Allele-Specific Regulation of Protein-Protein Interactions.
Release_Year 2019
PMID 31518125
DOI 10.1021/jacs.9b05725