PPIRE11804

Target Protein Information
Protein_Name NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Protein_Sequence MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
Organism_Source Homo sapiens
Functional_Classification NAD-dependent deacetylases
Cellular_Localization Nucleus
Gene_Names SIRT3
UniProt_ID Q9NTG7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3K4Cr(1-15)
Peptide_Sequence ARTXQTARKSTGGKA
Peptide_Length 15
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification X4=crotonyl lysine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1489.65
Aliphatic_Index 20.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.46667
Charge_at_pH_7 3.99739
Isoelectric_Point 12.53175
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 770.57000
X_logP_energy -13.67586
Interaction Information
Affinity KD=25.1 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4V1C
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach.
Release_Year 2014
PMID 25369635
DOI 10.7554/eLife.02999