PPIRE11845

Target Protein Information
Protein_Name Synaptotagmin-1
Protein_Sequence MVSESHHEALAAPPVTTVATVLPSNATEPASPGEGKEDAFSKLKEKFMNELHKIPLPPWALIAIAIVAVLLVLTCCFCICKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAVKK
Organism_Source Homo sapiens
Functional_Classification C2 domain-containing proteins
Cellular_Localization Plasma membrane
Gene_Names SYT1
UniProt_ID P21579
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SV2A Cluster-2 peptide pSer81+pThr84
Peptide_Sequence EGGASXDAXEGHDED
Peptide_Length 15
Peptide_SMILES C[C@H](NC(=O)CNC(=O)CNC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification X6=phosphoserine; X9=phosphothreonine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1402.26
Aliphatic_Index 13.33333
Aromaticity 0.00000
Average_Rotatable_Bonds 3.13333
Charge_at_pH_7 -5.90444
Isoelectric_Point 3.53184
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 743.43000
X_logP_energy -12.64110
Interaction Information
Affinity KD=900 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4V11
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1.
Release_Year 2015
PMID 25673844
DOI 10.1523/JNEUROSCI.4248-14.2015