PPIRE11866

Target Protein Information
Protein_Name Tol-Pal system protein TolB
Protein_Sequence MKQALRVAFGFLILWASVLHAEVRIVIDSGVDSGRPIGVVPFQWAGPGAAPEDIGGIVAADLRNSGKFNPLDRARLPQQPGSAQEVQPAAWSALGIDAVVVGQVTPNPDGSYNVAYQLVDTGGAPGTVLAQNSYKVNKQWLRYAGHTASDEVFEKLTGIKGAFRTRIAYVVQTNGGQFPYELRVSDYDGYNQFVVHRSPQPLMSPAWSPDGSKLAYVTFESGRSALVIQTLANGAVRQVASFPRHNGAPAFSPDGSKLAFALSKTGSLNLYVMDLASGQIRQVTDGRSNNTEPTWFPDSQNLAFTSDQAGRPQVYKVNINGGAPQRITWEGSQNQDADVSSDGKFMVMVSSNGGQQHIAKQDLATGGVQVLSSTFLDETPSLAPNGTMVIYSSSQGMGSVLNLVSTDGRFKARLPATDGQVKFPAWSPYL
Organism_Source Escherichia coli (strain K12)
Functional_Classification translocation proteins
Cellular_Localization Extracellular
Gene_Names tolB
UniProt_ID P0A855
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ColE9 Tpep32-47
Peptide_Sequence GASDGSGWSSENNPW
Peptide_Length 15
Peptide_SMILES C[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1550.52
Aliphatic_Index 6.66667
Aromaticity 0.13333
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -1.99979
Isoelectric_Point 3.55007
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 735.21000
X_logP_energy -11.88670
Interaction Information
Affinity KD=0.92 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2IVZ
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Competitive recruitment of the periplasmic translocation portal TolB by a natively disordered domain of colicin E9.
Release_Year 2006
PMID 16894158
DOI 10.1073/pnas.0603433103