PPIRE11884

Target Protein Information
Protein_Name Tropomyosin alpha-1 chain
Protein_Sequence MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEERSKQLEDELVALQKKLKGTEDELDKYSESLKDAQEKLELADKKATDAESEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAQKDEEKMEIQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERAEERAELSESKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLTDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
Organism_Source Gallus gallus
Functional_Classification actin-binding proteins
Cellular_Localization Plasma membrane
Gene_Names TPM1
UniProt_ID P04268
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name (HHPHG)3
Peptide_Sequence HHPHGHHPHGHHPHG
Peptide_Length 15
Peptide_SMILES N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1714.79
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.93333
Charge_at_pH_7 0.81617
Isoelectric_Point 8.07865
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 702.47000
X_logP_energy -7.70950
Interaction Information
Affinity IC50=1.25 uM
Affinity_Assay solid-phase competition binding assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Rational development of high-affinity T-cell receptor-like antibodies.
Release_Year 2004
PMID None
DOI 10.1158/0008-5472.CAN-04-0755