PPIRE11900

Target Protein Information
Protein_Name Ribonuclease pancreatic
Protein_Sequence MALKSLVLLSLLVLVLLLVRVQPSLGKETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV
Organism_Source Bos taurus
Functional_Classification ribonucleases
Cellular_Localization Extracellular
Gene_Names RNASE1
UniProt_ID P61823
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name S-peptide(1-15)
Peptide_Sequence KETAAAKFERQHXDS
Peptide_Length 15
Peptide_SMILES C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification X13=norleucine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1674.79
Aliphatic_Index 20.00000
Aromaticity 0.06667
Average_Rotatable_Bonds 3.86667
Charge_at_pH_7 0.09230
Isoelectric_Point 7.54974
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 808.79000
X_logP_energy -10.55073
Interaction Information
Affinity KD=25 uM
Affinity_Assay spectrophotometric assay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title RNase S complex bearing arginine-rich peptide and anti-HIV activity.
Release_Year 2005
PMID 15476294
DOI 10.1002/jmr.725