PPIRE11916

Target Protein Information
Protein_Name Proliferating cell nuclear antigen
Protein_Sequence MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS
Organism_Source Homo sapiens
Functional_Classification sliding clamp
Cellular_Localization Nucleus
Gene_Names PCNA
UniProt_ID P12004
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name p21mu-M147I
Peptide_Sequence KRRQTSITDFYFHSK
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1914.15
Aliphatic_Index 26.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 4.26667
Charge_at_pH_7 3.08789
Isoelectric_Point 10.88579
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 856.78000
X_logP_energy -9.09796
Interaction Information
Affinity KD=11.1 nM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Unlocking the PIP-box: A peptide library reveals interactions that drive high-affinity binding to human PCNA.
Release_Year 2021
PMID 33984330
DOI 10.1016/j.jbc.2021.100773