PPIRE11945

Target Protein Information
Protein_Name TRAF-interacting protein with FHA domain-containing protein A
Protein_Sequence MTSFEDADTEETVTCLQMTVYHPGQLQCGIFQSISFNREKLPSSEVVKFGRNSNICHYTFQDKQVSRVQFSLQLFKKFNSSVLSFEIKNMSKKTNLIVDSRELGYLNKMDLPYRCMVRFGEYQFLMEKEDGESLEFFETQFILSPRSLLQENNWPPHRPIPEYGTYSLCSSQSSSPTEMDENES
Organism_Source Homo sapiens
Functional_Classification adaptor proteins
Cellular_Localization Cytoplasm
Gene_Names TIFA
UniProt_ID Q96CG3
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name E5A pThr9-TIFA1-15
Peptide_Sequence MTSFADADXEETVTC
Peptide_Length 15
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O
Chemical_Modification X9=phosphothreonine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1576.67
Aliphatic_Index 32.66667
Aromaticity 0.06667
Average_Rotatable_Bonds 3.33333
Charge_at_pH_7 -4.05955
Isoelectric_Point 3.29497
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 700.84000
X_logP_energy -9.74800
Interaction Information
Affinity KD=160 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4YM4
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses.
Release_Year 2015
PMID 26389808
DOI 10.1021/acs.biochem.5b00500