PPIRE11950

Target Protein Information
Protein_Name Circumsporozoite protein
Protein_Sequence EALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSRSLGENDDGNNNNGDNGREGKDEDKRDGNNEDNEKLRKPKHKKLKQPADGNPDPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANGNNAVKNNNNEEPSDQHIEKYL
Organism_Source Plasmodium falciparum (isolate le5)
Functional_Classification sporozoite surface proteins
Cellular_Localization Extracellular
Gene_Names CSP
UniProt_ID P05691
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 29
Peptide_Sequence NANPNANPNANPNAN
Peptide_Length 15
Peptide_SMILES C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1506.51
Aliphatic_Index 26.66667
Aromaticity 0.00000
Average_Rotatable_Bonds 2.80000
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 789.07000
X_logP_energy -15.21310
Interaction Information
Affinity KD=53 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 6B5O
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Release_Year 2018
PMID 29554083
DOI 10.1038/nm.4512