PPIRE11957

Target Protein Information
Protein_Name Neuronal calcium sensor 1
Protein_Sequence MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV
Organism_Source Rattus norvegicus
Functional_Classification calcium sensor proteins
Cellular_Localization Cytoplasm
Gene_Names Ncs1
UniProt_ID P62168
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name D2R peptide
Peptide_Sequence NIEFRKAFLKILHSR
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(N)=O)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1872.25
Aliphatic_Index 110.66667
Aromaticity 0.13333
Average_Rotatable_Bonds 4.33333
Charge_at_pH_7 3.09007
Isoelectric_Point 11.65090
Number_of_Hydrogen_Bond_Acceptors 24
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 775.86000
X_logP_energy -4.64196
Interaction Information
Affinity KD=40 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 5AER
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1)Peptides Using Different Modes of Interactions.
Release_Year 2015
PMID 25979333
DOI 10.1074/jbc.M114.627059